Article Name: How Cells Tolerate DNA Damage: Start Signal for Cell Survival Program Identified
Author: Nathan Seppa
Date: November 17th, 2009
Magazine: Science Daily
Summary:
Cancer researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have gained new insights into how cells react to DNA damage. They have shown that the protein "PARP-1", which detects DNA damage, activates the transcription factor "NF-kappaB. NF-kappaB" triggers a survival program, which blocks programmed cell death. The activation of "NF-kappaB" is thought to be one of the potential causes for tumor cell resistance to chemo and radiation therapy.
Thoughts:
It's interesting, how almost every week new research and new innovations come out all relating to cancer. It really displays how much we don't know about cancer, and how much we have yet to learn.
http://www.sciencedaily.com/releases/2009/11/091116103441.htm
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